MINNEAPOLIS -- Mitch Garver had four hits and drove in a career-high six runs and Chase De Jong picked up his first major league win as the Minnesota Twins completed a doubleheader sweep of the Chicago White Sox with a 12-4 victory on Friday night at Target Field in Minneapolis.

Garver, usually a catcher but playing first base in his first game since suffering a concussion after taking a foul ball off his mask in against the New York Yankees on Sept. 12, had a two-run double in the first and a RBI double in the second inning as the Twins jumped out to a 7-0 lead.

He added a two-run single in the third inning to make it 10-1 and an RBI single in the fifth inning that extended Minnesota's lead to 11-2.

Garver had a chance to tie the Minnesota single-game record for RBIs (eight) shared by Glenn Adams (1977) and Randy Bush (1989) in the seventh inning when he came up with runners at second and third and no outs, but he grounded to first.

Robbie Grossman went 2-for-4 and drove in three runs, and Joe Mauer went 2-for-4 with a walk and scored twice for Minnesota (76-84) which won its fourth straight game. Jake Cave also went 2-for-4 with a walk and scored three runs, and Jorge Polanco and Juan Graterol each scored twice.

De Jong (1-1), obtained July 30 from Seattle along with first baseman Ryan Costello for reliever Zach Duke, allowed four hits, including solo homers to Jose Rondon and Kevan Smith, over six innings in his eighth big league start, four of them with the Twins. He walked one and struck out four.

Lucas Giolito (10-13) took the loss, allowing seven runs on five hits and four walks in just 1 1/3 innings for Chicago (62-98), finishing the season with an MLB-worst 6.13 ERA.

The White Sox must win at least one of the two remaining games of the series to avoid losing 100 games in a season for the first time since 1970 (56-106).

With the sweep, Minnesota, which won the opener 2-1 earlier Friday, improved to 28-12 at Target Field since June 24 and 47-32 overall this season.

Jose Berrios struck out nine batters while giving up one run and three hits over seven innings, and Robbie Grossman had two hits and two walks to lead the Twins to a 2-1 victory on Friday afternoon in the first game of the split doubleheader.

It was just the third win since pitching in the All-Star Game for Berrios (12-11), who became the eighth player in Minnesota history to record 200 strikeouts in a season when he got Daniel Palka to whiff in the sixth inning.

Berrios, who walked four, struck out the side in both the first and sixth innings and became the first Twins pitcher to hit the 200-strikeout mark since Francisco Liriano in 2010, finishing with 202 strikeouts in 192 1/3 innings to go with a 3.84 ERA.

Trevor May struck out both batters he faced to pick up his second save. Left-hander Taylor Rogers gave up one hit over 1 1/3 innings to extend his scoreless innings streak to 25 innings dating back to July 30.

Joe Mauer went 2-for-4 and scored a run, and Willians Astudillo drove in the winning run with a sacrifice fly for Minnesota (75-84), which won its third game in a row. It was the 20th RBI in 27 games for Astudillo.

Reynaldo Lopez (7-10) gave up two runs on four hits and five walks and struck out five to take the loss for Chicago (62-97), which fell two games behind Detroit (64-95) in the battle for third place in the American League Central.

Mauer opened the game with an infield single, advanced to third on a double by Jake Cave and then scored on a groundout by Tyler Austin to give the Twins an early 1-0 lead.

The White Sox tied it in the third on an infield RBI single by Leury Garcia, driving in Tim Anderson, who reached base on a fielder's choice.

Lopez started the sixth by walking Cave, Robbie Grossman and Austin to load the bases. But the Twins managed just a one-out sacrifice fly to center by Astudillo to drive in Cave for what proved to be the game-winning run.

The White Sox nearly tied it in the eighth when Avisail Garcia drilled what turned out to be a two-out, 346-foot single off the front of the limestone flower bed overhang at the top of the right field fence that Max Kepler quickly retrieved. Palka then struck out to end the inning.

The White Sox must win at least one of the two remaining games of the series to avoid losing 100 games in a season for the first time since 1970 (56-106).

With the sweep, Minnesota improved to 28-12 at Target Field since June 24 and 47-32 overall this season.